Wei Shi, Ph.D. Assistant Professor of Chemistry and Physics

Field of Interest

Biopharmaceutical Chemistry and Targeted Drug Delivery. Synthesize asymmetric functional curcumin derivatives for anticancer, and anti-Alzheimer's disease (AD) activity. Drug design based on natural products activity.  Synthesis and characterization of manganese complexes to study light-induced multistep oxidation on artificial photosynthesis by EPR, electrochemistry, and UV-vis spectra. , I also maintain a collaborative research effort with Dr. Krishnaswami Raja (College of Staten Island, CUNY).  Our latest project is on “The Synthesis of a Water/Plasma Soluble, Non-Cytotoxic, ‘Clicked’ Sugar-Derivative of Curcumin with Amplified Bio-Efficacy in Modulating Amyloid-b and Tau Peptide Aggregation”.

Courses Taught at Felician College

CHEM-105 Principles of Chemistry
CHEM 403 Physical Chemistry I
CHEM 404 Physical Chemistry I
PHYS-103 General Physics I
PHYS-104 General Physics II

Publications

““Clicked ” Sugar-Curcumin Conjugate: Modulator of Amyloid- and Tau Peptide Aggregation at Ultra-low Concentrations”.
ACS Chemical Neuroscience. 2011, 2, 694−699. Sukanta Dolai, Wei Shi, Christopher Corbo, Chong Sun, Saadyah Averick, Dinali Obeysekera, Mina Farid, Alejandra Alonso, Probal Banerjee Krishnaswami Raja. (http://pubs.acs.org/doi/abs/10.1021/cn200088r?prevSearch=%255BContrib%253A%2Bwei%2Bshi%255D&searchHistoryKey=)
“A General Methodology Towards Drug/Dye Incorporated Living Copolymer-Protein Hybrids: (NIRF Dye-Glucose) Copolymer-Avidin/BSA Conjugates as Prototypes”.
Biocojuate Chemistry. 2009, 20, 1595–1601. W. Shi, S. Dolai, S. Averick, S S. Fernando, J A. Saltos, W. L’Amoreaux, P. Banerjee, K. S. Raja. (http://pubs.acs.org/doi/abs/10.1021/bc900142y?prevSearch=%255BContrib%253A%2Bwei%2Bshi%255D&searchHistoryKey=)
“The concept of a green drug, curcumin and it’s derivatives as a model system.”
Mini-Reviews in Organic Chemistry. 2009, 6(2), 152-158. K.S. Raja; R. Balambika; S. Dolai; W. Shi. (http://www.benthamdirect.org/pages/b_viewarticle.php?articleID=3153329)
“Biotin-functional oligo(p-phenylene vinylene)s synthesized using click chemistry. ”
” Tetrahedron Letters. 2008, 49(45), 6386-6389. Vundyala, Neeraja; Sun, Chivin; Sidime, Francoise; Shi, Wei; L'Amoreaux, William; Raja, Krishnaswami; Peetz, Ralf M. (http://www.sciencedirect.com/science/article/pii/S0040403908015931)
“Synthesis of a novel biotin-PEG copolymer with reactive chain end by atom transfer radical polymerization.”
Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 2008, 49(1), 212-213. Wei Shi, Sukanta Dolai, Saadyah, Averick, Arijrt Sengupta, Ralf M. Peetz, Krishnaswami Raja.
“Synthesis of Mono- functional Curcumin Derivatives, Clicked Curcumin Dimer and A PAMAM Dendrimer Curcumin Conjugate forTtherapeutic Applications.”
Org. Lett. 2007; 9 (26): 5461-5464. Shi, W., Dolai. S., Rizk, S., Hussain, A., Tariq, H., Averick. S., Amoreaux, W. L., Idrissi, A. E. l, Banerjee, P., Raja, K.S. (http://pubs.acs.org/doi/abs/10.1021/ol702370m?prevSearch=%255BContrib%253A%2Bwei%2Bshi%255D&searchHistoryKey=)
“Redox Chemistry of a Dimanganese(II,III) Complex with an Unsymmetric ligand: Water Binding, Deprotonation and Accumulative Light-Induced Oxidation”,
Eur. J. Inorg. Chem. 2006, 24, 5033-5047. Magnus F. Anderlund, Joakim Högblom, Wei Shi, Ping Huang, Lars Eriksson, Högni Weihe, Stenbjörn Styring, Björn Åkermark, Reiner Lomoth, Ann Magnuson. (http://onlinelibrary.wiley.com/doi/10.1002/ejic.200600676/full)
“Synthesis and Structure of a Six-coordinated Manganese (III) Complex and Its Reaction Activity with Superoxide Anion”,
Journal of Coordination Chemistry 2006, 59, 119-130. Wei Shi, Yang Liu, Bin Liu, Yingkai Xu, Yuguang Song, Yangping Liu, Qiu Tian, Guangzhi Xu, Stenbjörn Styring, Ping Huang. (http://www.tandfonline.com/doi/full/10.1080/00958970500249814)
“Highly efficient photoactivation of Mn-depleted photosystem II by imidazole-liganded manganese complexes”,
Journal of Biological Inorganic Chemistry. 2006, 11(5), 626-632. Liu Bin, Shen Ping Ping, Shi Wei, Song Yu Guang, Li Wei; Nie Zhou, Liu Yang. (http://link.springer.com/article/10.1007/s00775-006-0111-z)
“A New Unsymmetric di-Manganese Complex supports Five Different Oxidation States; progress towards artificial photosynthesis”,
In: Photosynthesis: Fundamental Aspects to Global Perspectives (eds A. van der Est and D. Bruce), 2005, 1077-1079.Ann Magnuson, Magnus F. Anderlund, Joakim Högblom, Wei Shi, Reiner Lomoth, Licheng Sun, Stenbjörn Styring and Björn Åkermark.
“Structural Elucidation and Photosynthetic Mimicking of Bis (2,6-bis (benzimidazol -2-yl) pyridine) manganese (II)”,
Chinese J. Chem. 2003, 21(6), 659-664. Wei Shi, Wei Li, Ping-Ping Shen, Ying-Kai Xu, Hong-Mei Wang, Mei Shi, Yang Liu. (http://onlinelibrary.wiley.com/doi/10.1002/cjoc.20030210616/abstract)
“Synthesis, Characterization and Activity Study of 2–D Polymeric Complex [MnNa(Salicylate)2(CH3OH)(H2O)]nּ0.5nH2O”,
Chemical Journal of Chinese Universities. 2003, 24 (3), 516-518. Wei Shi, Ying-Kai Xu, Hong-Mei Wang, Yang Liu. (http://www.cjcu.jlu.edu.cn/CN/abstract/abstract13934.shtml)
Office Location:
Kirby Hall 124
Contact Phone:
(201) 559-6289

Education

Ph.D., Chinese Academy of Science (2003)
M.S., Shandong University (2000)
B.S., Shandong University (1995)

Positions Held

Felician College, Assistant Professor (2010-present)
College of Staten Island, CUNY, Post Doctoral Fellow (2006-2010)
Uppsala University, Post Doctoral Fellow ( 2003-2005)